Crowther, Damian C.: search on Z-Library

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1

CCT complex restricts neuropathogenic protein aggregation via autophagy

Pavel, Mariana, Imarisio, Sara, Menzies, Fiona M., Jimenez-Sanchez, Maria, Siddiqi, Farah H., Wu, Xiaoting, Renna, Maurizio, O’Kane, Cahir J., Crowther, Damian C., Rubinsztein, David C.

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 3.86 MB

english, 2016

2

Endoplasmic reticulum dysfunction in neurological disease

Benoit D Roussel, Antonina J Kruppa, Elena Miranda, Damian C Crowther, David A Lomas, Stefan J Marciniak

Journal:

The Lancet Neurology

Year:

2013

Language:

english

File:

PDF, 598 KB

english, 2013

3

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

Bolognesi, Benedetta, Kumita, Janet R., Barros, Teresa P., Esbjorner, Elin K., Luheshi, Leila M., Crowther, Damian C., Wilson, Mark R., Dobson, Christopher M., Favrin, Giorgio, Yerbury, Justin J.

Journal:

ACS Chemical Biology

Year:

2010

Language:

english

File:

PDF, 2.30 MB

english, 2010

4

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

Thomas Rival, Richard M. Page, Dhianjali S. Chandraratna, Timothy J. Sendall, Edward Ryder, Beinan Liu, Huw Lewis, Thomas Rosahl, Robert Hider, L. M. Camargo, Mark S. Shearman, Damian C. Crowther, D

Journal:

European Journal of Neuroscience

Year:

2009

Language:

english

File:

PDF, 617 KB

english, 2009

5

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer’s model

Khabirova, Eleonora, Chen, Ko-Fan, O’Neill, John S., Crowther, Damian C.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.28 MB

english, 2016

6

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

Luheshi, Leila M., Hoyer, Wolfgang, de Barros, Teresa Pereira, van Dijk Härd, Iris, Brorsson, Ann-Christin, Macao, Bertil, Persson, Cecilia, Crowther, Damian C., Lomas, David A., Ståhl, Stefan, Dobson

Journal:

Year:

2010

Language:

english

File:

PDF, 625 KB

english, 2010

7

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster model of Alzheimer's Disease

Costa, Rita, Speretta, Elena, Saraiva, Maria João, Crowther, Damian C., Cardoso, Isabel

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 50 KB

english, 2011

8

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

Kohlhoff, Kai J., Jahn, Thomas R., Lomas, David A., Dobson, Christopher M., Crowther, Damian C., Vendruscolo, Michele

Journal:

Integrative Biology

Year:

2011

Language:

english

File:

PDF, 1.79 MB

english, 2011

9

α 1 -Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

Ekeowa, Ugo I., Gooptu, Bibek, Belorgey, Didier, Hägglöf, Peter, Karlsson-Li, Susanna, Miranda, Elena, Pérez, Juan, MacLeod, Ian, Kroger, Heike, Marciniak, Stefan J., Crowther, Damian C., Lomas, David

Journal:

Clinical Science

Year:

2009

Language:

english

File:

PDF, 604 KB

english, 2009

10

Free Cholesterol Induces Higher β-Sheet Content in Aβ Peptide Oligomers by Aromatic Interaction with Phe19

Zhou, Xiaolin, Xu, Jie, Crowther, Damian Christopher

Journal:

Year:

2012

Language:

english

File:

PDF, 1.45 MB

english, 2012

11

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus

Journal:

Acta Neuropathologica Communications

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

12

An RNAI screen for genes that modify human amyloid induced paralysis in caenorhabditis elegans facilitates functional analysis of candidate risk factors for Alzheimer's disease

M. Moloney, Aileen, Fraboulet, Sandrine, Link, Christopher D., Williams, Julie, Lomas, David A., Crowther, Damian, Sattelle, David B.

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

13

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin

Knaupp, Anja S., Keleher, Shani, Yang, Li, Dai, Weiwen, Bottomley, Stephen P., Pearce, Mary C., Crowther, Damian Christopher

Journal:

Year:

2013

Language:

english

File:

PDF, 319 KB

english, 2013

14

[Methods in Enzymology] Amyloid, Prions, and Other Protein Aggregates, Part B Volume 412 || A Drosophila Model of Alzheimer's Disease

Crowther, Damian C.

Year:

2006

Language:

english

File:

PDF, 218 KB

english, 2006

15

Neuroserpin Phenotypes in Transgenic Drosophila are Rescued by the Alzheimer's β-amyloid peptide: In Vitro and in Vivo Correlations

Crowther, Damian C., Belorgey, Didier

Journal:

Clinical Science

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002

16

Protein misfolding and disease: from the test tube to the organism

Leila M Luheshi, Damian C Crowther, Christopher M Dobson

Journal:

Current Opinion in Chemical Biology

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

17

Nucleation of α 1 -Antichymotrypsin Polymerization †

Crowther, Damian C., Serpell, Louise C., Dafforn, Timothy R., Gooptu, Bibek, Lomas, David A.

Journal:

Year:

2003

Language:

english

File:

PDF, 259 KB

english, 2003

18

Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

Luheshi, Leila M., Tartaglia, Gian Gaetano, Brorsson, Ann-Christin, Pawar, Amol P., Watson, Ian E., Chiti, Fabrizio, Vendruscolo, Michele, Lomas, David A., Dobson, Christopher M., Crowther, Damian C.

Journal:

Year:

2007

Language:

english

File:

PDF, 554 KB

english, 2007

19

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid β peptide toxicity

Ott, Stanislav, Vishnivetskaya, Anastasia, Malmendal, Anders, Crowther, Damian C.

Journal:

Neurobiology of Aging

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

20

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

Fabre, Kristin M., Delsing, Louise, Hicks, Ryan, Colclough, Nicola, Crowther, Damian C., Ewart, Lorna

Journal:

Advanced Drug Delivery Reviews

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

21

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

Thomas R. Jahn, Kai J. Kohlhoff, Michael Scott, Gian Gaetano Tartaglia, David A. Lomas, Christopher M. Dobson, Michele Vendruscolo, Damian C. Crowther

Journal:

Journal of Neuroscience Methods

Year:

2011

Language:

english

File:

PDF, 708 KB

english, 2011

22

Prion-induced toxicity in PrP transgenic Drosophila

Alana M. Thackray, Farooq Muhammad, Chang Zhang, Margaret Denyer, John Spiropoulos, Damian C. Crowther, Raymond Bujdoso

Journal:

Experimental and Molecular Pathology

Year:

2012

Language:

english

File:

PDF, 898 KB

english, 2012

23

Disease, Diagnosis and Decisionsby Graham W. Bradley

Review by: Damian C. Crowther

Journal:

Journal of Medical Ethics

Year:

1995

Language:

english

File:

PDF, 569 KB

english, 1995

24

Central and peripheral circadian clocks and their role in Alzheimer's disease

Chauhan, Ruchi, Chen, Ko-Fan, Kent, Brianne A., Crowther, Damian C.

Journal:

Disease Models & Mechanisms

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

25

Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ40

Chen, Yi-Ru, Huang, Hsien-bin, Lo, Chi-Jen, Wang, Chih-Ching, Ho, Li-Kang, Liu, Hsin-Tzu, Shiao, Ming-Shi, Lin, Ta-Hsien, Chen, Yi-Cheng, Crowther, Damian Christopher

Journal:

Year:

2013

Language:

english

File:

PDF, 5.54 MB

english, 2013

26

The management of primary fallopian tube carcinoma

HOWARD GURNEY, DAMIAN MURPHY, DEREK CROWTHER

Journal:

BJOG: An International Journal of Obstetrics & Gynaecology

Year:

1990

Language:

english

File:

PDF, 332 KB

english, 1990

27

Retro-inversal of Intracellular Selected β-Amyloid-Interacting Peptides: Implications for a Novel Alzheimer’s Disease Treatment

Acerra, Nicola, Kad, Neil M., Griffith, Douglas A., Ott, Stanislav, Crowther, Damian C., Mason, Jody M.

Journal:

Year:

2014

Language:

english

File:

PDF, 5.66 MB

english, 2014

28

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival

Thackray, Alana M., Muhammad, Farooq, Zhang, Chang, Di, Ying, Jahn, Thomas R., Landgraf, Matthias, Crowther, Damian C., Evers, Jan Felix, Bujdoso, Raymond

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 586 KB

english, 2012

29

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems

El-Khoury, Riyad, Kaulio, Eveliina, Lassila, Katariina A, Crowther, Damian C, Jacobs, Howard T, Rustin, Pierre

Journal:

Free Radical Biology and Medicine

Year:

2016

Language:

english

File:

PDF, 572 KB

english, 2016

30

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis

Lynda K. Sharp, Meera Mallya, Kerri J. Kinghorn, Zhen Wang, Damian C. Crowther, James A. Huntington, Didier Belorgey, David A. Lomas

Journal:

Year:

2006

Language:

english

File:

PDF, 347 KB

english, 2006

31

Familial conformational diseases and dementias

Damian C. Crowther

Journal:

Year:

2002

Language:

english

File:

PDF, 248 KB

english, 2002

32

Unravelling the twists and turns of the serpinopathies

Benoit D. Roussel, James A. Irving, Ugo I. Ekeowa, Didier Belorgey, Imran Haq, Adriana Ordóñez, Antonina J. Kruppa, Annelyse Duvoix, Sheikh Tamir Rashid, Damian C. Crowther, Stefan J. Marciniak, David

Journal:

Year:

2011

Language:

english

File:

PDF, 320 KB

english, 2011

33

Characterisation of serpin polymers in vitro and in vivo

Didier Belorgey, James A. Irving, Ugo I. Ekeowa, Joanna Freeke, Benoit D. Roussel, Elena Miranda, Juan Pérez, Carol V. Robinson, Stefan J. Marciniak, Damian C. Crowther, Claire H. Michel, David A. Lom

Journal:

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

34

P1-082: Using a Drosophila model of Alzheimer’s disease to direct the search for genetic modifiers of Aβ1-42 neurotoxicity

Richard Page, Damian C. Crowther, Dhia Chandraratna, Ed Ryder, Rosa Bautista-Llacer, David A. Lomas

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 65 KB

english, 2006

35

BRICHOS efficiently inhibits beta-amyloid 42 aggregation and toxicity in Drosophila melanogaster

Hermansson, Erik, Loganathan, Krishnapriya, Crowther, Damian, Westermark, Gunilla, Winblad, Bengt, Johansson, Jan, Presto, Jenny

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 68 KB

english, 2013

36

Therapeutic targets from a Drosophila model of Alzheimer’s disease

Damian C Crowther, Kerri J Kinghorn, Richard Page, David A Lomas

Journal:

Current Opinion in Pharmacology

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

37

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies

Crowther, Damian C, Belorgey, Didier, Miranda, Elena, Kinghorn, Kerri J, Sharp, Lynda K, Lomas, David A

Journal:

European Journal of Human Genetics

Year:

2003

Language:

english

File:

PDF, 159 KB

english, 2003

38

Blockade of the suprascapular nerve: a radiological and cadaveric study comparing landmark and ultrasound-guided blocking techniques

Lancaster, Sarah T., Clark, Damian A., Redpath, Yvette, Hughes, David M., Crowther, Mark A., Lewis, Simon M.

Journal:

Shoulder & Elbow

Year:

2013

Language:

english

File:

PDF, 957 KB

english, 2013

39

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer disease

Younan, Nadine D., Chen, Ko-Fan, Rose, Ruth-Sarah, Crowther, Damian C., Viles, John H.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 2.08 MB

english, 2018

40

The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans

Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J., Williams, Julie, Lomas, David A., Oliver, Stephen G., Favrin, Giorgio, Sattelle, David B., Crowther, Damian C., Iijima, Koichi M.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

41

P1-111: Using a Drosophila model of Alzheimer’s disease to identify genetic modifiers of Ab1-42-induced oxidative stress

Thomas Rival, Damian C. Crowther, Page Richard, Ryder Ed, Bautista-Llacer Rosa, Lomas A. Lomas

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

42

Puromycin-sensitive aminopeptidase rescues β-amyloid toxicity in Alzheimer's disease

Kruppa, Antonina, Chandraratna, Dhia, Irving, James, Marciniak, Stefan, Townsend, Matthew, Crowther, Damian, Lomas, David

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

43

AN ASSAY FOR SEEDED PROTEIN AGGREGATION DETECTS ABETA SEEDS IN SERUM

Crowther, Damian Christopher, van Vliet, Liisa, Kuhaudomlarp, Sue, Gielen, Fabrice, Yan, Jing, Azhar, Mayida, Hinault, Marie-Pierre, Hollfelder, Florian

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 160 KB

english, 2014

44

Serpins: Implications of a mobile reactive centre

Damian C. Crowther, Dyfed L.I. Evans, Robin W. Carrell

Journal:

Current Opinion in Biotechnology

Year:

1992

Language:

english

File:

PDF, 924 KB

english, 1992

45

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers : Implications for the epilepsy seen in the dementia FENIB

Didier Belorgey, Lynda K. Sharp, Damian C. Crowther, Maki Onda, Jan Johansson, David A. Lomas

Journal:

Year:

2004

Language:

english

File:

PDF, 368 KB

english, 2004

46

Alzheimer's disease: insights from Drosophila melanogaster models

Aileen Moloney, David B. Sattelle, David A. Lomas, Damian C. Crowther

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 2.60 MB

english, 2010

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